RTB: Glutathione, a nutrient found in whole foods, is lacking in patients given the AIDS diagnosis; supplementing with glutathione improves health and reduces concurrent TB infections.
Glutathione and Growth Inhibition of Mycobacterium Tuberculosis in Healthy and HIV Infected Subjects
Vishwanath Venketaraman, Tatanisha Rodgers, Rafael Linares, Nancy Reilly, Shobha Swaminathan, David Hom, Ariel C Millman, Robert Wallis and Nancy D Connell; AIDS Research and Therapy 2006, 3:5doi:10.1186/1742-6405-3-5
20 February 2006
Intracellular levels of glutathione are depleted in patients with acquired immunodeficiency syndrome in whom the risk of tuberculosis, particularly disseminated disease is many times that of healthy individuals. In this study, we examined the role of glutathione in immunity against tuberculosis infection in samples derived from healthy and human immunodeficiency virus infected subjects. Our studies confirm that glutathione levels are reduced in peripheral blood mononuclear cells and in red blood cells isolated from human immunodeficiency virus-infected subjects (CD4>400/cumm).
Furthermore, treatment of blood cultures from human immunodeficiency virus infected subjects with N-acetyl cysteine, a glutathione precursor, caused improved control of intracellular M. tuberculosis infection. N-acetyl cysteine treatment decreased the levels of IL-1, TNF-?, and IL-6, and increased the levels of IFN-? in blood cultures derived from human immunodeficiency virus-infected subjects, promoting the host immune responses to contain M. tuberculosis infection successfully.
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