Crack cocaine: effect modifier of RNA viral load and CD4 count in HIV infected African American women.

http://www.ncbi.nlm.nih.gov/pubmed/17127396

This report supports a view of deleterious effects due to cocaine use in humans.

University of Miami School of Medicine, Department of Epidemiology and Public Health, Miami, FL 33136, USA. rduncan@med.miami.edu

Robert Duncan, Paul Shapshak, J Bryan Page, Francesco Chiappelli, Clyde B McCoy, Sarah E Messiah

This study reports on the role of cocaine as effect modifier of the association of CD4+ cell counts and RNA viral load. HIV-1 seropositive (n = 80) and seronegative (n = 42) African American women (AAW) crack cocaine smokers were recruited. Increasing cocaine use, based on self-reports and laboratory values, significantly exacerbates the immunopathology of HIV-1 in a dose-response manner, confirmed by a non-linear drop in CD4+ cell number for a given viral load in HIV+ AAW. This report supports a view of deleterious effects due to cocaine use in humans.

Other papers by authors:

Front Biosci. 2005 Jan 1;10 :135-42 15574356 (P,S,G,E,B)

Quantification of HIV GAG RNA using real time reverse transcriptase PCR.
Paul Shapshak, Robert Duncan, Clyde B McCoy, J Bryan Page

Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, Miami, FL 33136, USA. pshapsha@med.miami.edu Bioinformation. 2006 ;1 (3):86-8 17597862 (P,S,G,E,B)

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