RTB: This study makes it clear that putative HIV sequences are really commonly occuring endogenous retroviral sequences (ERV or HERV). Here, conserved (clearly related) sequences to what they’re calling HIV, are found in (non-AIDS) monkeys and human beings. Which means that these sequences aren’t so special after all.
The trouble is, researchers never bother to look at all the variable, “wildly mutating” material they call “HIV” in comparison with all the material evolution and ERV researchers find, because it would spoil their belief that there was a unique, single (though wily and constantly mutating, therefore never-the-same) entity which, despite being shown to barely exist as a separate phenomena, and which does not negatively effect T-Cells, and which is not a sexually-transmitted disease, is still their most worshiped God in their loony AIDS religion.
Endogenous retrovirus-related sequences exist within the normal genomic DNA of all eukaryotes, and these endogenous sequences have been shown to be important to the nature and biology of related exogenous retroviruses and may also play a role in cellular functions.
[Endogenous retroviruses aren’t viruses – they are transposable elements, and other cellular machinery that have not yet been properly understood, because medicine operates in a war-model, seeing everything as an invader or threat]
To date, no endogenous sequences related to human immunodeficiency virus type1 (HIV-1) have been reported.
Herein we describe the first report of the presence of nucleotide sequences related to HIV-1 in human, chimpanzee, and rhesus monkey DNAs from normal uninfected individuals.
[Well, I guess somebody finally bothered to look?]
We also present the isolation and characterization of two of these endogenous HIV-1-related sequences, EHS-1 and EHS-2.
[HIV-1 ‘related?’ In uninfected humans, monkeys and chimps? Wha? Huh? I thought…well, I guess ‘we still have a lot to learn.’]
With use of low-stringency Southern blot hybridization, complex banding patterns were detected in human DNA with 5′ and 3′ HIV-1-derived probes. When an HIV-1 env region probe was used, we detected a less complex, conserved banding pattern in human dNA as well as a related but distinct banding pattern in chimpanzee and rhesus monkey DNAs.
EHS-1 and -2 were cloned from normal human genomic DNA libraries by using the env region probe.Clone EHS-1 shows sequence similarity with the domain of the envelope cellular protease cleavage site of HIV-1, while EHS-2 has sequence similarity to the over-lapping reading frame for Rev and gp4i.
Stringent hybridization of EHS-1 back to primate genomic DNA indicates two distinct EHS-1 loci in normal human DNA, an identical band pattern in chimpanzee DNA, and a single locus in rhesus monkey DNA. Likewise, EHS-2 is present as a single highly conserved locus in all three species. An oligonucleotide derived from EHS-2 across a region of near identity to HIV-1 detects a complex banding pattern in all primates tested similar to that seen with the 3’HIV-1 probe.
[They’re saying that they’re ‘non-HIV’ gene sequence is pretty darned close to their ‘HIV’ sequence. Go figure…]
These data suggest that most of the HIV-1-related sequences identified in primate DNA share a common core of nucleic acid sequence found in both EHS-2 and rev and that some of these H1V-1-related sequences have additional larger regions of sequence similarity to HIV-1.
[Common core…do they mean that all of these elements are…similar? Despite being from “pos” and “negative” monkeys, humans and apes? Golly…
What’s this “HIV-1 related?” In HIV-negative people? Wouldn’t that indicate that what they’re looking at are Endogenous Retro-elements?
Yes. Yes, it would].